Cause of polycystic ovary syndrome discovered at last

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The most common cause of female infertility – polycystic ovary syndrome – may be caused by a hormonal imbalance before birth. The finding has led to a cure in mice, and a drug trial is set to begin in women later this year.

Polycystic ovary syndrome affects up to one in five women worldwide, three-quarters of whom struggle to fall pregnant. The condition is typically characterised by high levels of testosterone, ovarian cysts, irregular menstrual cycles, and problems regulating sugar, but the causes have long been a mystery. “It’s by far the most common hormonal condition affecting women of reproductive age but it hasn’t received a lot of attention,” says Robert Norman at the University of Adelaide in Australia.

Continue Reading.

THIS IS UNUSUAL CONTENT FOR MY BLOG BUT

Y’ALL THIS IS HUGE

!!!!!

Just going to point out that as much as this excerpt here describes it as affecting “fertility” and oh woe, they can’t get pregnant as easy…uh, it’s also something that can make them fucking miserable and POTENTIALLY KILL THEM

Here’s the thing: ovaries normally do produce cysts. They’re supposed to! To an extent. They produce like, a tiny number, maybe one, each menstrual cycle, because the egg that is ready to be hypothetically fertilized, is PUSHED OUT to the fallopian tube, by an actual cyst.

This is the normal process, in the “4 out of 5″ women who don’t have PCOS.

In PCOS, though, my understanding is that the cyst production does not happen in this nice, orderly fashion, only happening approximately every few weeks; instead, it goes haywire and happens all over the place and WAY too much (hence “polycystic”). 

Left unchecked, this can cause the organ to become damaged, it can cause it to swell and even press on other things in the abdomen and put OTHER parts of the body at risk, can cause all sorts of awful things.

IIRC ( @tekka-wekka I think you know more about this than I do, by all means please correct me if I’m wrong about any of it?) it tends to cause a lot of pain or heavy bleeding during many people’s menstrual cycles and, as noted, causes them to be more irregular – so it’s basically a disability, one that can be LIFE-THREATENING.

And guess what the main treatment for PCOS is, to keep the cysts in line and regulate the menstrual cycle properly?

Hormone-regulating pills.

You know, the ones normally labeled “birth control”. 

This was what Sandra Fluke was testifying about a few years back, during health care debates, by the way. She had a friend who had EXACTLY this condition, and the fact that Georgetown’s student health coverage would NOT cover her “birth control” medication meant that she went without it for three months…and her ovaries, filled with cysts, enlarged so much that she required EMERGENCY SURGERY (to remove them entirely, IIRC). 

Which is why Sandra Fluke was FIRMLY arguing for increased access to “birth control” medications; because leaving aside questions of autonomy, it’s an actual literal life-or-death health necessity for many people! Such as those with PCOS in specific!

But I digress.

My point is: this is a condition that goes beyond “fertility” issues; it requires a LOT of people to go on pretty much (IIRC) permanent hormonal regulation to carefully regulate their menstrual cycles in order to NOT DIE. Because, left untreated, it can, in fact, literally pose that risk. (And depending on the specific hormonal birth control in question – this may have the trade off of things like a higher stroke risk, so that’s…that’s a thing, too, oops)

So uh. This?

This is REALLY good news.

But not JUST for folks with PCOS who want to have biological children; it’s literally just good news in general, because this could be LIFE-SAVING research??

I just wanted to point that out because, like, I don’t think a lot of people are aware of PCOS and how it can potentially KILL YOU,  and there’s a lot of misconceptions about ovarian/uterine health in general, and like… and I think some folks might scroll past this thinking it’s mostly about “fertility”?

When it’s actually a condition that impacts WAY more than that, and chances are very very good you actually know someone with this condition, whether you realize it or not.

Reblogging for the additional info. Most of the folks I know with this don’t give a shit about fertility. They just want to stop needing S5+ painkillers to function at least 25% of the time.

The thing about this is, if IVF drugs were an effective treatment for PCOS, there wouldn’t be so many women with PCOS who go through multiple rounds of IVF. 

IT’S NOT CAUSED BY BEING FAT.

If there’s one thing I want people to take away from this article, it’s that PCOS IS NOT CAUSED BY BEING FAT.

(Or at the very least, not caused by the person who has it being fat. DFK how maternal weight is involved, but since PCOS is hereditary, more likely PCOS also isn’t caused by your mom being fat.)

The connection between weight and PCOS is that because fat tissue has a role in hormone production, being fat can exacerbate symptoms somewhat. However, PCOS also causes weight gain, so telling people with PCOS to lose weight is useless advice. It just so happens that people with less fatty tissue who have PCOS, have slightly more manageable symptoms.

And peopel took this to mean that fat causes PCOS, because people hate anyone who weighs more than like 90lbs.

Cause of polycystic ovary syndrome discovered at last

prismatic-bell:

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machine-dove:

Other cartoons that the publisher refused to print before firing Rogers:

A political cartoonist who had satirized every President during his 25 years at the paper is fired for drawing Trump cartoons.

“This is precisely the time,” Pittsburgh mayor Bill Peduto (often the target of Rogers’ cartoons) said, “when the constitutionally protected free press – including critics like Rob Rogers – should be celebrated and supported, and not fired for doing their jobs. This decision, just one day after Trump labeled the news media is ‘our country’s biggest enemy.’“

Y’know, like dictators always do under fascist regimes.

The story on The Guardian: X

Want to support him?

https://www.patreon.com/robrogers

He has a patreon.

FMAB does breasts right.

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theishvalanalchemist:

i-am-mother-universe:

theishvalanalchemist:

strawbebehmod:

theishvalanalchemist:

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image

Their boobs move. Like…realistically move. As in, the way actual breasts would motion if a woman made that movement without an over the top exaggeration and the camera is framed in a way so that it’s clearly not supposed to be sexual the way most anime would stage it. The scenes in question are meant to be taken seriously so the animators and direction is take things seriously. Either it’s just a character walking down a hall or clapping her hands. 

If this were any other action/adventure anime, the camera angle would’ve been something like this for Winry’s introduction:

This is weird, but what I find so sexy about Riza is, well… How she isn’t sexualized. Like, she isn’t a pure sex object in nonstop sexy outfits. She’s a beautiful military woman, and she dresses appropriately for the role. Along with that she’s NEVER used as the ‘sexy distraction’ trope that women often are used for. She has a good role, she’s a fighter, but also has a kind heart for her friends.

That and more are reasons Riza is my favorite female anime character, and FMAB is my favorite anime.

Well said my friend.

I think there was only one instance of jiggle physics and that was with lust but that was when they were trying to make a joke about havoc having a thing for boobs and the joke was more about havoc than lust having big breasts.

“You fell into my booby trap” (proceeds to paralyze Havoc afterwards)

What I also love is that their boobs are in equal proportion to every other body part. Like, yeah, a character might have bigger boobs, but she also had a big waist/hips/legs/etc to go with it, so the largeness doesn’t feel fake. Plus, they never draw attention to the sexual stuff, and the only exception was the joke with Havoc. And it was posed in a way that made it feel like less of a raunchy boob joke and more of a joke on Havoc and how his attraction to boobs is what led him to be deceived, which doesn’t leave female viewers uncomfortable, or feeling like their body is constantly the butt of a joke, like some other animes do

That’s a good point that I didn’t realize. All of characters in the show have equally proportioned bodies. 

Ed’s muscles get larger as he gets older but never reaches John Cena level of jacked since he’s still under 6 feet tall. He’s always presented as ripped and not ‘bulky’ like Sig or Alex. 

Riza is about the same height as adult Ed, but they have different body styles thus the word for her would be toned. She’s still lean but her muscles and body shape are the same aren’t ‘compact’. 

Fmab follows the basic body designs for males and female characters and doesn’t exaggerate a specific feature to the point where it’s comedic. It makes it’s bed, and lies in it.  

Every time I see a girl in just about any other action/adventure (shonen) anime I just think:

“is your back okay? You need a doctor? Hey Thomas! Call Lucy a chiropractor!”

or better yet:

“Good Lord! Get this man a sandwich!”

The only real exception to the whole body proportion thing is ALEX LOUIS ARMSTRONG

But his ridiculously bulky muscles are used largely as a comedic element, in which the overly toned nature of his body is commented on as the “freak of nature” kind of idea and definitely not presented as if that’s some kind of expectation for anyone else in the show. 

#fma#whispers: its bc a woman made it

don’t fucking whisper it scream it from the rooftops: IT’S BC A WOMAN MADE IT.

kinasty:

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And this is why we used to make cars out of STEEL instead of FIBERGLASS! Sure, fiberglass is a lot lighter in weight and hence a hell of a lot better for gas mileage. But you hit anything at more than 20 mph and the entire body explodes off the fucking thing, and now you’re spending more to repair the car than it’s worth because you need a entire front end, read end, or side panel. They can’t just take the damaged section off, beat it out with a hammer, sand it, and repaint it.

Everything is made with the idea of it being easier to replace than to maintain, aka planned obsolescence. Thanks, capitalism

You guys are obscenely, dangerously wrong. 

It’s not planned obsolescence, it’s physics.

Modern cars crumple to absorb and distribute the forces of impact in an accident in an effort to protect the occupants. When cars didn’t have those crumple zones, the occupants, being the soft, squishy things they were, took those forces and were mangled or killed in horrible ways. Also, those older cars took hidden damage that often went unnoticed and made them very dangerous to drive. 

I recently watched a TV show where a small sedan was run over by the trailer of an eighteen-wheeler. Run. Over. They had to unwrap the crumpled ball of a car from the undercarriage of that trailer. Guess what? The driver suffered only minor injuries because the car collapsed in exactly the way it was designed to so that she, in the very strong frame surrounding the passenger compartment, was protected. 

And no, don’t thank capitalism for these modern cars. Thank Ralph Nader and countless other safety activists who worked tirelessly to make car manufacturers accountable for the safety of the people who drove their cars. 

legit

at one point I was straight up abt to purchase an old corvair bc they look cool but nader was right they’re coffins on wheels